Stites Lab

Use of mechanistic models to integrate and analyze multiple proteomic datasets

Stites EC, Aziz M, Creamer MS, Von Hoff DD, Posner RG, Hlavacek WS

Biophysical Journal, 2015


Cooperation between Noncanonical Ras Network Mutations

Stites EC, Trampont PC, Haney LB, Walk SF, Ravichandran KS

Cell Reports, 2015


Allosteric activation of functionally asymmetric RAF kinase dimers

Hu J, Stites EC, Yu H, Germino EA, Meharena HS, Stork PJ, Kornev AP, Taylor SS, Shaw AS

Cell, 2013


Chemical kinetic mechanistic models to investigate cancer biology and impact cancer medicine

Stites EC

Physical Biology, 2013


Innovations of the rule-based modeling approach

Chylek LA, Stites EC, Posner RG, Hlavacek WS

Systems Biology, 2013


The response of cancers to BRAF inhibition underscores the importance of cancer systems biology

Stites EC

Science Signaling, 2012


Specification, annotation, visualization and simulation of a large rule-based model for ERBB receptor signaling

Creamer MS, Stites EC, Aziz M, Cahill JA, Tan CW, Berens ME, Han H, Bussey KJ, Von Hoff DD, Hlavacek WS, Posner RG

BMC Systems Biology, 2012


Mechanistic modeling to investigate signaling by oncogenic Ras mutants

Stites EC, Ravichandran KS

Wiley Interdisciplinary Reviews. Systems Biology and Medicine, 2012


Genome-wide characterization of pancreatic adenocarcinoma patients using next generation sequencing

Liang WS, Craig DW, Carpten J, Borad MJ, Demeure MJ, Weiss GJ, Izatt T, Sinari S, Christoforides A, Aldrich J, Kurdoglu A, Barrett M, Phillips L, Benson H, Tembe W, Braggio E, Kiefer JA, Legendre C, Posner R, Hostetter GH, Baker A, Egan JB, Han H, Lake D, Stites EC, Ramanathan RK, Fonseca R, Stewart AK, Von Hoff D

PloS One, 2012


Mathematical investigation of how oncogenic ras mutants promote ras signaling

Stites EC, Ravichandran KS

Methods in Molecular Biology, 2012


Modeling membrane localization: case study of a Ras signaling model

Stites EC

Advances in Experimental Medicine and Biology, 2010


A systems perspective of ras signaling in cancer

Stites EC, Ravichandran KS

Clinical Cancer Research, 2009


Network analysis of oncogenic Ras activation in cancer

Stites EC, Trampont PC, Ma Z, Ravichandran KS

Science, 2007


Sensitivity and versatility of an adaptive system for controlling cyclic movements using functional neuromuscular stimulation

Stites EC, Abbas JJ

IEEE Transactions on Biomedical Engineering, 2000







Differences in sensitivity to EGFR inhibitors could be explained by described biochemical differences between oncogenic Ras mutants

Stites EC

bioRxiv, 2014


A quantitative systems pharmacology analysis of KRAS G12C covalent inhibitors

Stites EC and Shaw AS

bioRxiv, 2017


Analysis of RAS as a tumor suppressor

Kenney C and Stites EC

bioRxiv, 2017


A computational panel of pathological RAS mutants with implications for personalized medicine and genetic medicine

Kenney C and Stites EC

bioRxiv, 2017